Do You Have the Answers You Need to Determine the Best Treatment Option?
A liquid biopsy from Biocept gives you a new tool for profiling breast cancer—with a simple blood test.
You Need a Complete Answer to Provide the Best Treatment for Breast Cancer.
Choosing the most effective treatment for women with recurrent or newly diagnosed metastatic breast cancer depends on ER, PR and HER2 receptor status. These key targets help doctors understand which therapies have the best chance of success, and can also be used to help breast cancer patients qualify for clinical trials.
Published guidelines from ASCO and CAP establish new standards for determining biomarker status. These guidelines call for repeat biopsies in late-stage patients, as well as using excision biopsies to retest initial negative results. This helps ensure that patients don’t miss out on potentially effective targeted therapies.
Risks of biopsy in breast cancer
For many breast cancer patients, a metastatic biopsy may be difficult or impossible to obtain due to the location of the recurrent lesion—for example, bone, lung, brain or other hard to biopsy sites. Furthermore, the poor performance status of some patients makes a repeat biopsy risky.
Biocept’s innovative technology allows clinicians to evaluate key biomarkers such as ER, PR, HER2, FGFR1, AR, PD-L1 and others from a simple, non-invasive blood sample.
Monitoring cancer as it changes
Recent literature suggests that biomarker status can change between primary and metastatic disease. These findings suggest that the discordance of markers like ER, PR and HER2 can be over 10% when comparing the primary tumor to metastatic tumors.1
Discordance of biomarkers between primary and metastatic biopsies can be attributed to:
Biocept and liquid biopsies—Completing the Answer™
Whether you’re unable to safely obtain a repeat biopsy sample, or you need to monitor metastatic cancer for changes in biomarker status, a liquid biopsy from Biocept can help complete the answer.
Biocept has developed advanced methods for finding circulating cancer cells (CTCs) and oncogene mutation fragments (ctDNA) in the blood. This allows our CLIA-certified and CAP-accredited laboratory to perform predictive biomarker testing and provide the most up-to-date biomarker status from a non-invasive patient blood sample.
Validation studies have demonstrated that our technology has a high correlation between the biomarker status found in blood samples and traditional tissue biopsy. Studies site the discordance in receptor status from primary to metastatic disease.2 Biocept can test for predictive biomarkers to identify patients who may benefit from therapy changes or re-biopsy to improve outcomes.3
How does it work?
A liquid biopsy from Biocept is a fast, easy way to establish biomarker status.
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1. J Clin Oncol. 2013 Nov 1;31(31):3997-4013. doi: 10.1200/JCO.2013.50.9984. Epub 2013 Oct 7.
2. Annals of Internal Medicine, 2011 August 2; 155(3):137-144. doi:10.1059/0003-4819-155-3-20110820-00003
3. Cancer Medicine, 2013; 2(2): 226-233 doi:10.1002/cam4.70