About Liquid Biopsies
Circulating tumor cells (CTCs) are cells that have detached from a primary tumor and circulate in the bloodstream. CTCs may travel to other areas and create new tumors in different tissues or organs (metastases). Elevated CTCs at any time in the course of clinical treatment of metastic breast cancer are indicators of progression.
ctDNA stands for circulating tumor DNA. These fragments of non-cellular mutated DNA can find their way into blood through either apoptosis or necrosis of the solid tumor tissue. ctDNA can also be generated from circulating tumor cells (CTCs) that are released by a tumor into the blood stream, followed by degradation within the blood stream and a release of DNA contents.
The capture and detection of CTCs may have important prognostic and therapeutic implications because detection of tumor cells may have clinical utility in risk stratification in early cancer, in early detection of relapse, and in monitoring response to treatment. The presence of tumor cells circulating in the blood has been associated with shortened survival from various solid tumor cancers.
A prognostic test may indicate the outcome and course of a disease. A predictive test suggests likely response to a particular therapy. Information about the presence and number of CTCs has prognostic value. Biomarker status results indicate whether a patient is a candidate for tailored drug therapy and are therefore predictive.
Biocept’s testing platform is not designed to screen for cancer. It is intended to provide information to clinicians about the presence of CTCs, ctDNA, and other specific biomarkers, such as proteins and amplifications, from the CTCs. These results assist physicians in understanding the status of the disease and in making decisions on current and future therapy. Treatments for metastatic cancer have advanced over the past years, but diagnostic tools for selecting the appropriate pharmacologic agent have lagged. Liquid biopsy is an advanced tool available now for your physician.
About the Liquid Biopsy Tests
Biocept’s liquid biopsy is performed on a simple blood sample. No complex surgical biopsy for tissue is required. Additionally, there is no radiation exposure like a CT Scan, PET/CT or X-Ray. No fasting is necessary prior to the test. Consult with your doctor on preparation for either procedure if you have questions.
Liquid biopsy testing can be performed before, during, and after your therapy. You and your doctor should discuss the test, the frequency of the test, and what is appropriate for your unique situation.
Biocept, Inc., File 1689, 1801 W. Olympic Blvd., Pasadena, CA 91199-1689
Biocept Financial Assistance Program (BFAP) – is a program designed to aid those patients who have unique financial situations based upon income, expenses or financial hardship. By completing the application process, it is possible to reduce, or eliminate the patient’s financial responsibility. For Physicians and clients, please contact your representative for assistance. For patients, please contact our billing department at 888-492-4723.